The book “Black Education in White America” opened the window to show our State of American Education in general, and in particular, the Black education. American competitive intellectual output is falling behind globally and our educational superiority is going downhill. The nation is at risk! American education followed a segregated pathway since the birth of this Republic. Brutality of slavery and its legacy transformed a large segment of the African American population into a state of despair through the epigenetic modification of the structure of DNA that resulted neuro-behavioral, mental and other pathophysiological conditions. Toxic stress and traumatic experiences inflicted on Black people altered the function of various metabolic pathways that affected a child's cognitive abilities and executive functions via epi-genomic control passed from one generation to the next. Black education in White America provides scientific evidence which explain how slavery could inflict a kind of destruction on millions of children, women and adults. As epigenetics and its machinery of gene expression are influenced by the external environmental factors, so positive educational experiences and healthy outlooks and habits can also theoretically influence epi-genome to promote positive responses which will decrease the risk of pathophysiological conditions and lower the morbidity and mortality rates. Transformative power of education needs to be nurtured in America so that every child may educate him/herself with no hindrances from segregated, racist and demagoguery.